Pharmacometrics Modeling Skills
GenAI skills for building and evaluating pharmacometrics models
A skill is a file of instructions an AI assistant loads before a task. This project has two parts. The first writes a few skill files for building and evaluating pharmacometrics models, assembled from published guidance and from internal guidance documents turned into checklists that can be published. The second keeps a ranked list of the pharmacometrics skill files others have published, compiled each month by an agent against criteria set here. Nothing is built yet.
Documents
Specification 1: making the skill files. The goal, the first skill on model evaluation in nlmixr2 in two modes, the inputs, the yearly rebuild, and the questions still to settle.
Specification 2: the curated list. The categories, the quantitative ranking criteria, and the monthly agent run that finds, scores and publishes public skill files.
PMx Skills Index. The ranked list itself, compiled by Claude from Specification 2, with the evidence behind every score.
Proposal. One page: why skill files could replace static guidance documents, and the rules for consensus, position pages, review and governance.
References. The reading queue for the first reference list, with a status marker on every entry.