Selected Talks

Tutorials and conference presentations on pharmacokinetics and pharmacodynamics, model uncertainty and identifiability, CAR-T and solid tumour modelling, and target mediated drug disposition.

Published

September 6, 2026

Each talk is linked twice: a PDF hosted here, which opens anywhere, and the Google original, which is the editable copy.

Tutorials

Fundamental Concepts of PKPD

Introduction to Fundamental PK Concepts
PDF · Google Slides
From the 2018–2019 Novartis Academia-Industry Quantitative Hackathon.

Introduction to Fundamental PD Concepts
PDF · Google Slides
From the 2018–2019 Novartis Academia-Industry Quantitative Hackathon.

Causal Diagrams for Exposure-Response Analysis
PDF · Google Slides
For when correlation doesn’t imply causation. From the 2021 Novartis Academia-Industry Quantitative Hackathon.

Model Uncertainty and Identifiability

Assessing the Uncertainty and Predictive Accuracy of Mechanistic Models; with Applications in CML
PDF · Google Drive · YouTube video
FDA Systems Pharmacology Group Meeting 2020, and Laboratory for Systems Medicine at University of Florida Group Meeting 2022.

Importance of Assessing Model Convergence and Practical Identifiability During Model Development
PDF · Google Slides
ACoP 2018.

Oncology

CAR-T cells

Chimeric Antigen Receptor T cell Therapies: A Review of Cellular Kinetic-Pharmacodynamic Modeling Approaches
PDF · Google Slides
ACoP 2021.

The Cellular Kinetics and Anti-Tumor Dynamics of Kymriah
PDF · Google Drive
ACoP 2019.

Solid Tumor Modeling

Using Longitudinal Solid Tumor Data to Improve Drug Development Decisions
PDF · Google Slides
ACoP 2013.

Dose Selection in Solid Tumor Trials: Making use of All Available Data
PDF · Google Slides
PhUSE 2013.

Chronic Myeloid Leukemia (CML)

Bcr-Abl Kinetics Suggests that Self Renewing Leukemic Cells are Reduced During Imatinib Treatment
PDF · Google Slides
ASH 2009.

Biologics

Assessing the Identifiability of Models for Target Mediated Drug Disposition using a New Metric of Potency
PDF · Google Slides
SIAM Life Sciences 2016.

Two New Parameters for Characterizing Ligand Binding Systems
PDF · Google Slides
ACoP 2017.