Projects

Longer-running work: open-source tools, and working documents for problems that do not fit in a blog post.

R packages

synpmx

Generating realistic synthetic PK/PD datasets, so that analysis workflows, teaching material, and tooling can be developed and shared without exposing real clinical data.

xgx

Eploratory Graphics : a guide to the graphics that make pharmacokinetic and pharmacodynamic data interpretable, with worked examples for each figure type.

xgxr

The R package behind xgx: helper functions for the axes, scales, and summaries that exploratory pharmacokinetic and pharmacodynamic graphics keep needing.

PMX projects

Working documents that record current thinking on a problem.

TCE-IPDE

PMX project

Draft

Does escalating dose within a patient reach a confirmable active dose sooner in a first-in-human T-cell engager trial, and does the time it saves outweigh the extra visits…

TCE-CRS-tolerance

PMX project

Draft

Cytokine release syndrome risk often falls as step-up doses rise. Can the published epcoritamab tolerance model explain that, and can it be fit to publicly available data…

Exposure metric guide

PMX project

Draft

Turning the Choosing a PK Metric R Markdown file into a PMX Tools page: what the source holds, what changed in the conversion, and what is left.

Sizing studies

PMX project

Draft

How many patients a Phase 1/2 expansion cohort needs to characterize a dose-response or biomarker-response relationship: Frank Harrell’s rule of thumb, Richard Riley’s…

Logistic regression for dose finding

PMX project

Draft

Picking a method, glm against Bayesian alternatives, and picking the right diagnostics for a fitted model. Both drafts, to be extended as time allows.

GenAI

Claude Code at Work

GenAI

A talk to the group on using Claude Code for open-source pharmacometrics: four worked examples, how it is set up, and what has to be checked before the output is trusted.

Agentic engineering for data analysis tools

GenAI

Draft

Writing the requirements and the checks before commissioning an agent to build inside them: what is already in place here, how the initial spec gets written, and how the…

Matlab tools

Matlab Tools for Tumor Spheroid and Collagen Network Analysis

AIRE, FIRE and BEAMS: MATLAB tools written during the PhD thesis and postdoc, for tumour spheroid invasive radii, network geometry from confocal images, and beam network…