Pharmacometrics Tools
Checklists and cheat sheets
PMX guide
Checklists and cheat sheets for scoping a modelling activity, making graphics, presenting and giving feedback, and writing R that someone else can validate. Freely available tools only.
The resources below are designed to help improve the quality and efficiency of Pharmacometrics work. In the spirit of Atul Gawande’s Checklist Manifesto, you’ll find below many short checklists and cheatsheets. Many great books and software exist on the topics below, and the focus here is on freely available tools.
Scoping
- Context of Use Table for scoping modeling activity
- Uncertainty Checklist
- Presentation on Managing Uncertainty
- Causality Checklist and Guidance for PMX: PDF · Google Doc
- Dose Finding Framework
- Selecting an Exposure Metric — four questions to settle before an exposure-response analysis
Graphics
- Effective Visual Communication tutorial
- Effective Visual Communication Webpage
- Graphics Principles Cheat Sheet
- Exploratory Graphics (xGx) Website
- Exploratory Graphics (xGx) Cheat Sheet
- See-Value — line up plots for visual inference
- CompareRates — for comparing response rates between two arms
Presentations and soft skills
- Presentation Checklist
- Presentation Evaluation Feedback Form: PDF · Google Doc
- Guide to Giving and Receiving Feedback
- Communication Methods (email vs video call vs in person): PDF · Google Doc
- Holding people accountable: PDF · Google Doc
Tutorials
- Intro. to Fundamental PK Concepts: PDF · Google Slides
- Intro. to Fundamental PD Concepts: PDF · Google Slides
Open source code (R)
- R Coding Checklist: PDF · Google Doc
- Validation Checklist: PDF · Google Doc
- xgxr Package for Exploratory Graphics
- nlmixr2 Package for Nonlinear Mixed Effect Modeling
- ggPMX Package for Diagnostic Plots
- xgxr + nlmixr + ggPMX tutorials (YouTube)
Other tools
- Grams to Molar Equations: PDF · Google Doc
- Practical PK Calculator
- FDA search for drug reviews