B cell reset in autoimmune diseases

What returns after depletion, and whether it predicts remission

B cell immunophenotypes, complementary biomarkers and evidence connecting immune reconstitution with durable response.

How is B cell reset characterized, and how does it correlate with long-term response? The evidence supports measuring the composition and self-reactivity of returning B cells alongside clinical outcomes. A universal reset threshold that predicts lasting remission has not been established in the studies reviewed here.

Documents

• Working specification. Scope, evidence standards, proposed sampling and an analysis plan for testing prediction.
• Evidence review. Immunophenotype definitions, complementary biomarkers, clinical evidence and interpretation.
• References. Recommended reading, claim-specific source checks and remaining access limitations.