Publishing the 3 RECIST Lesion Model

Turning a 2011 ASCO poster into a citable preprint

Pharmacometrics
Index of the documents in the pmx-afinitor-3-lesion-types project: writing up the RECORD-1 everolimus model of target, nontarget and new lesions as a preprint on bioRxiv, medRxiv or Zenodo.
Last edited

October 14, 2026

At ASCO 2011, Stein, Carter, Hollaender, Motzer and Sarr presented a model of the RECORD-1 phase 3 trial of everolimus (Afinitor) in metastatic renal cell carcinoma that describes all three RECIST lesion types: the sum of target lesion diameters, the progression of nontarget lesions, and the appearance of new lesions. The three predictions combine into a progression-free survival prediction for each patient. The model exists only as a poster (PDF). This project writes it up as a preprint with a DOI, so it can be cited.

Documents

  • Working specification. What the poster holds, the choice of server, what the manuscript needs that the poster lacks, and the steps to posting.
  • Tumor Models of Nontarget and New Lesions. A review of the published models that describe nontarget or new lesions, and where the poster sits among them.
  • References. The poster, the trial papers, the companion abstracts, and a marker on each recording whether the claim drawn from it has been checked.
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